Selected publications

Nucleotide metabolism in cancer cells fuels a UDP-driven macrophage crosstalk promoting immunosuppression and immunotherapy resistance - Scolaro T , Manco M, Pecqueux M, Amorim R, Trotta R, Van Acker H, Van Haele M, Shirgaonkar N, Wang L, Naulaerts S, Daniluk J, Prenen F, Varamo C, Ponti D, Doglioni G, Ferreira Campos AM, Fernandez Garcia J,  Radenkovic S, Rouhi P, Beatovic S, Tzoumpa A, Antoranz A, Sargsian A, Di Matteo M, Berardi E, Goveia J, Ghesquière B, Roskams T, Carmeliet P, Soenen S, Voets T, Manshian B, Fendt SM, Garg AD, DasGupta R, Wang Y, Topal B, Mazzone M# - 2024 - Nature Cancer - Accepted for publication

A metabolic gene survey pinpoints fucosylation as a key pathway underlying the suppressive function of regulatory T-cells in cancer - Pinioti S, Sharma H, Flerin NC, Yu Q, Tzoumpa A, Truso Cafarello S, De Bousser E, Callewaert N, Oldenhove G, Schlenner S, Thienpont B, Garg AD, Di Matteo M, Mazzone M^# - 2023 - Cancer Immunology Research - PubMed

Breast tumors interfere with endothelial TRAIL at the pre-metastatic niche to promote cancer cell seeding - Riera-Domingo C, Leite-Gomes E, Charatsidou I, Zhao P, Carrà G, Cappellesso F, Mourao L, De Schepper M, Liu D, Serneels J, Alameh M-G, Shuvaev V, Geukens T, Isnaldi E, Prenen H, Weissman D, Muzykantov VR, Soenen S, Desmedt C, Scheele CLGJ, Sablina A, Di Matteo M, Martín-Pérez R, Mazzone M^# - 2023 - Science Advances - PubMed

Targeting the bicarbonate transporter SLC4A4 overcomes immunosuppression and immunotherapy resistance in pancreatic cancer - Cappellesso F, Orban M-P, Shirgaonkar N, Berardi E, Serneels J, Neveu M-A, di Molfetta D, Piccapane F, Caroppo R, Debellis L, Ostyn T, Joudiou N, Mignion L, Richiardone E, Jordan B.F., Gallez B, Corbet C, Roskams T, Dasgupta R, Tejpar S, Di Matteo M, Taverna D, Reshkin S.J., Topal B, Virga F, Mazzone M^# - 2022 - Nature Cancer - PubMed

A collaborative synthetase - Mazzone M^# and Castegna A - Nature Chemical Biology - PubMed

Deletion of lactate dehydrogenase-A impairs oncogene-induced mouse hepatocellular carcinoma development - Serra M, Di Matteo M, Serneels J, Pal R, Trusso Cafarello S, Lanza M, Sanchez-Martin C, Castegna A, Mazzone M, Columbano A- 2022 - Cell Mol Gastroenter - PubMed

PlexinA4 mediates cytotoxic T cell trafficking and exclusion in cancer - Celus W, Oliveira AI, Rivis S, Van Acker HH, Landeloos E, Serneels J, Trusso Cafarello S, Van Herck Y, Mastrantonio R, Köhler A, Garg AD, Flamand V, Tamagnone L, Marine JC, Di Matteo M, Costa BM, Bechter O, Mazzone M^#. - 2021 - Cancer Immunology Res - PubMed

N-acetylaspartate release by glutaminolytic ovarian cancer cells sustains pro-tumoral macrophages - Menga M, Favia M, Spera I, Vegliante MC, Gissi R, De Grassi A, Laera L, Campanella A, Gerbino A, Canton M, Loizzi V, Pierri CL, Cormio G, Mazzone M^*, Castegna A^*. - 2021 - EMBO Reports - PubMed

Isolation and separation of murine tumor-associated macrophages (TAMs) subpopulations from orthotopic 4T1 breast tumors - Bieniasz-Krzywiec P, Martín-Pérez R, Riera Domingo C, Smeets A and Mazzone M - 2021 - STAR protocols - PubMed

How metabolism bridles cytotoxic T cells through epigenetic modifications - Van Acker H, Ma S, Scolaro T, Kaech SM, Mazzone M - 2021 - Trends in Immunology - PubMed

Macrophage miR-210 induction and metabolic reprogramming in response to pathogen interaction boost life-threatening inflammation - Virga F, Cappellesso F, Stijlemans B, Henze AT, Trotta R, Van Audenaerde J, Mirchandani AS, Sanchez-Garcia MA, Vandewalle J, Ordo F, Riera-Domingo C, Griffa A, Ivan C, Smits E, Laoui D, Martelli F, Langouche L, Van den Berghe G, Feron O, Ghesquière B, Prenen H, Libert C, Walmsley SR, Corbet C, Van Ginderachter JA, Ivan M, Taverna D, Mazzone M - 2021 - Science Advances - PubMed

ESDN inhibits melanoma progression by blocking E-selecting expression on endothelial cell - Coppo R, Orso F, Virga F, Dalmasso A, Baruffaldi D, Nie L, Clapero F, Dettori D, Quirico L, Grassi E, Defilippi P, Provero P, Valdembri D, Serini G, Sadeghi MM, Mazzone M^*, Taverna D^#,* - 2021 - Cancer Letters - PubMed

MicroRNA-mediated metabolic shaping of the tumour microenvironment - Virga F, Quirico L, Cucinelli S, Mazzone M, Taverna D, Orso F - 2021 - Cancers - PubMed

Metabolic traits ruling the specificity of the immune response in different cancer types - Flerin N, Cappellesso F, Pretto S, and Mazzone M - 2020 - Current opinion in Biotechnology - Pubmed

Macrophage-derived glutamine boosts satellite cells and muscle regeneration. - Shang M, Cappellesso F, Amorim R, Serneels J, Virga F, Eelen G, Carobbio S, Rincon MY, Maechler P, De Bock K, Ho PC, Sandri M, Ghesquière B, Carmeliet P, Di Matteo M, Berardi E, and Mazzone M - 2020 - Nature - PubMed

Glufosinate constrains synchronous and metachronous metastasis by promoting anti-tumor macrophages - Menga A, Serra M, Todisco S, Riera Domingo C, Ammarah U, Ehling M, Palmieri E, Di Noia M-A, Gissi R, Favia M, Pierri CL, Porporato P, Castegna A, Mazzone M - 2020 - EMBO Mol Med - PubMed

Impact of immunometabolism on cancer metastasis: a focus on T cells and macrophages. - Flerin NC, Pinioti S, Menga A, Castegna A, Mazzone M. - 2020 - Cold Spring Harbor perspectives in medicine - Pubmed

Metabolism tailors macrophage functions: one size does not fit all - Castegna A, and Mazzone M# - 2020 - Immunometabolism - Hapres

B55a/PP2A limits endothelial cell apoptosis during vascular remodeling: a complementary approach to kill pathological vessels - Ehling M, Celus W, Martín-Pérez R, Alba-Rovira R, Willox S, Ponti D, Cinta M, Jones E, Di Conza G, and Mazzone M - 2020 - Circulation Research - PubMed

Understanding metal dynamics between cancer cells and macrophages: competition or synergism? - Serra M, Columbano A, Ammarah U, Mazzone M#, and Alessio Menga. - 2020 - Front. Oncol. - PubMed

PoEMS edit breast cancer outcome. - Bieniasz-Krzywiec, P. and Mazzone, M - 2020 - Aging - Pubmed

An integrated Gene Expression Landscape Profiling Approach to Identify Lung Tumor Endothelial Cell Heterogeneity and Angiogenic Candidates. - Goveia, J., Rohlenova, K., Taverna, F., Treps, L., Conradi, L-C., Pircher, A., Geldhof, et al., Mazzone, M., et al., Carmeliet, P. - 2020 - Cancer Cell - Pubmed

Podoplanin-expressing macrophages are required for lymphangiogenesis and lymphatic metastasis in breast cancer - Bieniasz-Krzywiec P, Martín-Pérez R, Ehling M, Kroes R, Aldeni C, García-Caballero M, Prenen H, Noel A, Smeets A, Floris G, Van Ginderachter JA, and Mazzone M - 2019 - Cell Metabolism - Pubmed

Immunity, Hypoxia, and Metabolism - the ménage à trois of cancer: implications for immunotherapy - Riera Domingo C, Costa Granja S, Audige A, Baltazar F, Stockmann C, Ho PC, and Mazzone M - 2019 - Physiological Reviews - Pubmed

Blood Vessel Proximity Shapes Cancer Cell Metabolism - Virga, F, Ehling, M and Mazzone, M - 2019 - Cell Metabolism - Pubmed

Regulation of Blood and Lymphatic Vessels by Immune Cells in Tumors and Metastasis - Mazzone, M, and Bergers G - 2019 - Annu Rev Physio - Pubmed

Tumor-associated macrophages: a short compendium - Prenen H, and Mazzone M - 2019 - Cellular and Molecular Life Sciences - Pubmed

The reciprocal function and regulation of tumor vessels and immune cells offers new therapeutic opportunities in cancer - Missiaen R, Mazzone M, and Bergers G - 2018 - Seminars in Cancer Biology - Pubmed

Metabolism and TAM functions: it takes two to tango - Mazzone M, Menga A, and Castegna A - 2018 - FEBS J - Pubmed

Is there merit for MET-targeted therapies in Gastro-Oesophageal cancer? - Mazzone M, Finisguerra V, and Prenen H - 2018 - JAMA Oncology - Pubmed

Loss of Caveolin-1 in metastasis-associated macrophages drives metastatic growth through increased angiogenesis - Celus W, Di Conza G, Oliveira AI, Ehling M, Costa BM, Wenes M, and Mazzone M - 2017 - Cell Reports - Pubmed

Pharmacologic or genetic targeting of glutamine synthase skews macrophages towards an M1-like phenotype and strongly inhibits tumor metastasis - Palmieri E, Menga A, Martín-Pérez R, Quinto A, Riera-Domingo C, De Tullio G, Lamers W, Hooper D, Ghesquière B, Guarin A, Mazzone M#,* - 2017 - Cell Reports - Pubmed

PHD2 targeting overcomes breast cancer cell death upon glucose starvation in a PP2A/B55α-mediated manner - Di Conza G, Trusso Cafarello S, Zheng X, Zhang Q, and Mazzone M# - 2017 - Cell Reports - Pubmed

Blockade of glutamine synthetase enhances inflammatory response in microglial cells - Palmieri E, Menga A, Hooper D, Mazzone M#, Castegna A. - 2017 - Antioxidants & Redox Signaling - Pubmed

The mTOR and regulate PHD2 phosphorylation and fine tune HIF1α levels and colorectal cancer cell survival under hypoxia - Di Conza G, Cafarello ST, Loroch S, Mennerich D, Deschoemaeker S, Di Matteo M, Ehling, M, Gevaert K, Prenen H, Peiman Zahedi R, Sickmann A, Kietzmann T, and Mazzone M# - 2017 - Cell Reports - Pubmed

Macrophage metabolism controls tumor blood vessel morphogenesis and metastasis - Wenes M, Shang M, Di Matteo M, Goveia J, Martín-Pérez R, Serneels J, Prenen H, Ghesquière B, Carmeliet P, and Mazzone M - 2016 - Cell Metabolism - Pubmed

The impact of hypoxia on tumor associated macrophages (TAMs) - Henze A-T and Mazzone M - 2016 - J Clin Invest - Pubmed

Tumor-educated circulating monocytes are powerful candidate biomarkers for diagnosis and disease follow-up of colorectal cancer. - Hamm A, Prenen H, van Delm W, Di Matteo M, Wenes M, Delemarre E, Schmidt T, Weitz J, Sarmiento R, Dezi A, Gasparini G, Rothé F, Schmitz R, D’Hoore A, Iserentant H, Hendlisz A, and Mazzone M - 2016 - Gut - Pubmed

Vessel normalization in the spot-LIGHT of cancer treatment - Ehling M and Mazzone M#. - 2016 - Trends in Mol Med - Pubmed